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Peptide half-lives vary enormously
3, 6, 12
A power analysis ( = 0.05 and power = 0.90), based on data where a difference would be significant if the weight loss were 1 kg more than that in CT group with an expected standard deviation of 0.75, indicated that 13 patients would be needed in each group to detect significant difference [18]
Oral GLP-1 agonists havent quite caught on yet, primarily due to (1) issues with absorption, which necessitates higher dosing than injectables and may impact efficacy, and (2) fasting restrictions (must be taken on an empty stomach)
The injections last about 15 minutes and cost between 40-70 dollars
US$ 23.20
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US$ 26.41
US$ 20.49
