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Description

In hypoxic epithelial ovarian cancer, as a transcription factor of IGF-1, highly expressed ELF3-mediated secretion of IGF-1 and VEGF promoted endothelial cell proliferation, migration and tumor angiogenesis through activation of the tyrosine kinase pathway, whereas ELF3 silencing attenuated angiogenesis and tumorigenesis in a xenograft mouse model, demonstrating the pro-vascular effect of IGF-1 (39)

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It stays encapsulated during the journey through the stomach and the glutathione particles are released when they reach further down the intestines, where they can be easily absorbed through the gut lining into the bloodstream

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Laferrre, Blandine et al

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In clinical trials, CJC-1295 was well tolerated at doses of 3060 g/kg (no serious adverse events)

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Its molecular weight is approximately 3367 g/mol

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