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Priya Jaisinghani, an endocrinologist and obesity medicine specialist at NYU Langone Health, tells Flow Space

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When you inject exogenous synthetic HGH, your brain senses the massive artificial influx, realizes it no longer needs to do any work, and completely shuts down its natural production (a negative feedback loop)

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In this trial, semaglutide was given at 1 mg, the maintenance dose studied at the time

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This combined with exercise (which we know boosts dopamine) may be a viable option for weight loss

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Lancet Diabetes Endocrinol (2022) 10:40717

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