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Furthermore, lower CSF melatonin levels in AD patients are correlated with greater disease severity [229]

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Preclinical studies suggest hydrogen-rich water (HRW), typically administered at 0.81.6 ppm H in drinking water (510 ml/day per mouse), reduces neuropathic pain symptoms, allodynia, and hyperalgesia by modulating oxidative stress and inflammation

Key Takeaway: While GLP-1s work primarily through hormone receptors to control appetite and insulin, berberine works at the cellular level by activating the AMPK enzyme to regulate energy use