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It binds to the S1P 1 receptor, which is most abundantly expressed on vascular endothelial cells, and the activation of this receptor attenuates the activity of MMPs, causing syndecan-1 ectodomain shedding (132)

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A drug-drug interaction in vivo is considered likely when the ratio between the C max measured in plasma and the inhibitory constant (K i ) measured in vitro is higher than 0.1

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Both drug classes affect cardiovascular function, and their combined effects may lower blood pressure more than either alonea benefit that also carries monitoring obligations