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Patients should not discontinue Wegovy simply because they require prednisolone

It can be a good choice for patients who want meaningful weight loss without bariatric surgery or for those looking for a lower-cost alternative to long-term medication use

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67,68 Still, the presence of GLP-1 RA-specific psychiatric adverse events that may also be related to drug intolerance requires the development of a strategy to overcome this barrier for the better implementation of GLP-1RA therapy

These findings align well with our correlation analyses, in which butyrate levels positively correlated with muscle mass and function, while showing negative associations with the oxidative stress marker MDA and atrophy markers Atrogin-1 and MuRF-1