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5 While its primary endpoint (a composite including all-cause mortality, nonfatal MI, stroke, acute coronary syndrome, leg revascularization, and major leg amputation) did not reach significance, a main secondary composite endpoint (all-cause mortality, nonfatal MI, and stroke) showed a significant benefit with pioglitazone (hazard ratio [HR] 0.84

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They have also not been thoroughly tested like weight loss injections and pills have, so there is no clear list of the side effects these patches could cause, which is further complicated by different patches containing different ingredients

Always tell your provider if you are pregnant, trying to become pregnant, or nursing

Amino acids matter