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Benefits of B12 supplementation have been shown in a number of conditions, including diabetic neuropathy, back pain, mouth ulcers, autism spectrum disorder and elevated homocysteine levels, and it is generally considered to be very safe even at high dosages

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A recent large-scale multiethnic cohort study of individuals who did not have ASCVD clinically at baseline, which evaluated the combined effects of Lp(a) and hypertension on incident ASCVD, elevated Lp(a) significantly altered the relationship among hypertension and cardiovascular disease, and the Lp(a)-related risk of cardiovascular disease was not significant in patients without hypertension [126]

One challenge is that lanosterol is a big molecule

Food Res Int 163:112168