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PMID: 35778693 J Chromatogr A Preparation of thiol-free amino acid plasma matrix for quantification of thiol amino acids and their oxidized forms in human plasma by UPLC-MS/MS

Otherwise deficiency can be treated with vitamin B12 supplements, B12-fortified foods and natural B12 food sources

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The observed mitochondrial alterations are the suppression of the PDC, thereby lowering the conversion of pyruvate to acetyl-CoA and diminished mitochondrial ATP production from OXPHOS and glycolysis