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Genetic testing for classical-like EDS (clEDS) was negative in the three families (families 4, 6, and 7) without a clear autosomal dominant history and not performed in the others

Non-alcoholic fatty liver disease (NAFLD): Oxidative stress and glutathione depletion are characteristic findings in NAFLD and its more severe form, non-alcoholic steatohepatitis (NASH)

Moreover, some clinical trials have not shown significant effects of probiotics on cardiovascular-risk factors [101]

doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy

Dehydration: Alcohol is a diuretic, meaning it can lead to dehydration