Unlike prescription GLP-1 receptor agonists such as semaglutide, berberine is an unlicensed food supplement with modest clinical effects and variable product quality
Compounded Methylcobalamin injections are prepared outside the FDA approval process and are not reviewed by the FDA for safety, effectiveness, or quality
The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity
Topical Application This is what most people will use at home
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