By inhibiting COX enzymes, ibuprofen may disrupt the balance of pro- and anti-inflammatory mediators, potentially leading to increased oxidative stress
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Factors leading to SLE include: Genetic predisposition, including haplotype HLA-B8, -DR 3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins such as cigarette smoke Drugs in drug-induced LE Emotional upset
Br J Pharmacol 118: 941950
Zou J, Song Q, Shaw PC, Wu Y, Zuo Z, Yu R