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A Skeptical Take of Semaglutide for Cardiac Protection A preventive cardiologist offers a critical appraisal of the SELECT trial of Semaglutide (Wegovy) When the New England Journal of Medicine published the placebo-controlled SELECT trial of semaglutide in patients with established vascular disease, I had thought cardiology had discovered another disease-modifying drug
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When dose reduction is appropriate Phase 3 trials include provisions for dose reduction: Gastrointestinal adverse events or inadequate oral intake may warrant stepping down to a lower dose level see Retatrutide Side Effects for incidence rates by dose BMI reaching 22 kg/m or below , or perceived excessive weight loss, allows dose reduction Treatment is discontinued at BMI 18.5 kg/m or below How Often and When to Take Retatrutide Injection frequency once weekly by subcutaneous injection, on the same day each week
This can be particularly important for individuals who are obese or have a body mass index (BMI) of 30 or higher, as carrying excess weight can increase the risk of developing serious health conditions, such as type 2 diabetes, heart disease, and certain cancers
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