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These resistance mechanisms reduce intracellular drug accumulation and undermine treatment efficacy, posing a major challenge in the clinical management of fungal infections

Conceiving of the study, participated in its design and helping to draft the manuscript

Ejersted, C

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rotate Lamiophlomis rotate SM Shanzhiside methylester MAPK p38 mitogen-activated protein kinase DPN Diabetic peripheral neuropathy MCU Mitochondrial calcium uniporter UCP3 Uncoupling protein 3 DRP1 Dynamin-related protein 1 STZ Streptozotocin ERK Extracellular signal-regulated kinase MMP-2 Matrix metalloproteinases-2 MMP-9 Matrix metalloproteinases-9 NLRP3 NOD-like receptor protein 3 AGEs Advanced glycation end products CSA Cross-sectional area CM Chronic migraine TNC Trigeminal nucleus caudalis CGRP Calcitonin gene-related peptide ICP Intracranial pressure CSF Cerebrospinal fluid IIH Idiopathic intracranial hypertension Author contributions Y.H.: Writing-review & editing, Writing-original draft, Methodology, Validation, Supervision, Formal analysis