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Beyond its effects on blood glucose regulation, semaglutide influences weight management through its impact on appetite and food intake
Given that DPP-IV cleavage of GLP-1 736 amide generates GLP-1 936 amide, which has been described as either a low affinity weak partial agonist or antagonist of the GLP-1R [17], [18] and that GLP-1 936 amide can be present at five- to ten-fold higher concentrations than GLP-1 736 amide [10], the present study examined potential interactions between compound 2 and GLP-1 936 amide at the GLP-1R
Cells 12:2793 van den Bogaard EH, Elias PM, Goleva E, Berdyshev E, Smits JP, Danby SG, Cork MJ, Leung DY (2023) Targeting skin barrier function in atopic dermatitis
10.1007/s13300-013-0024-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 123.Schweizer A, Dejager S, Foley JE, Kothny W
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