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Long acting agonists appear to penetrate permeable areas of the blood-brain barrier and act directly on neurons with GLP-1R in the paraventricular nucleus (PVN) and Area Postrema (56, 102, 105)

The 2.5 mg dosage is for treatment initiation and is not intended for glycemic control

The GLP-1 and PYY co-expressing L-cells are typically considered to be involved in the regulation of energy homeostasis, in addition to other functions

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Bright Red Tongue Possible Causes: Vitamin B12, folate, or iron deficiency (smooth, beefy tongue) Kawasaki disease (in children) Scarlet fever Fever or infection Clinical Insight: Consider checking CBC, iron studies, and vitamin levels