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In terms of the magnitude of fat mass reduction in controlled research settings: Semaglutide (GLP-1 alone): ~1015% body weight Tirzepatide (GLP-1 + GIP): ~1622% body weight Retatrutide (GLP-1 + GIP + Glucagon): ~2429% body weight (Phase 2 data) This stepwise increase with each additional receptor target is a remarkable demonstration of pharmacological synergy and has driven enormous interest in the triple-agonist research space

In fact, a recent review of 37 studies on weight loss showed that those who rely on GLP-1 drugs tend to gain back the weight at a faster rate when they stop treatment, as compared to those who rely on behavioral change