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Pregnancy and lactation A retrospective observational study reported that daily oral supplementation with 600 mg of lipoic acid (racemic mixture) during pregnancy and without interruption from a period spanning between week 10 and week 30 of gestation and until the end of week 37 was not associated with any adverse effect in mothers and their newborns (114)

104 Tryptophan and its derivative, 5-hydroxytryptophan (5-HTP), have been used to treat depression, anxiety, and sleep disorders, 103,105 and higher dietary tryptophan intake was linked to lower risk of depression and increased self-reported sleep duration in an observational study with 29,687 participants