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Early-phase clinical trial data, including results from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), demonstrated significant weight reduction in adults with obesity (without type 2 diabetes), with participants receiving the highest dose losing a mean of approximately 24% of their body weight over 48 weeks

Improper technique can reduce the effectiveness of the injection or cause unnecessary discomfort

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Using the wrong solution type is another frequent error: substituting tap water, saline, or an unverified liquid for pharmaceutical-grade bacteriostatic or sterile water introduces contamination risk regardless of how carefully everything else is handled

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