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Bemben, D.D

A study published in the Journal of Medicinal Chemistry identified a compound from fenugreek seeds, designated N55, that binds to GLP-1 and enhances the potency of GLP-1 in stimulating GLP-1 receptor signaling

They are approved only for type 2 diabetes management and, for specific agents like semaglutide (Wegovy) and liraglutide (Saxenda), chronic weight management in adults with obesity or overweight with comorbidities

Abstract Aims/hypothesis Our aim was to assess treatment discontinuation, reinitiation and switching between drugs within the same drug class for glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter 2 (SGLT2) inhibitors in individuals with type 2 diabetes

Older GLP-1 receptor agonists such as exenatide and liraglutide have previously shown modest promise in people with schizophrenia, but their effects have been relatively limited and side effects were common