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Although this phenomenon is considered the primary pathway of melanocyte destruction in vitiligo, the presence of melanocyte-specific T cells is not sufficient, as they have also been found in healthy individuals, showing an anergic phenotype.19,20 Regulatory T cells The imbalance between pro- and anti-inflammatory signaling is crucial in the pathogenesis of vitiligo

In twice-per-week fasting (such as the so-called 5:2 diet), fasting is performed on 2 non-consecutive days of the week, and the remaining 5 days are for habitual food intake (Scholtens et al., 2020)

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