glp 1 for longevity Are GLP-1s Drugs? GLP 1 medications are changing

SGLT2 inhibitors are one medication class that clinicians may consider for many adults with type 2 diabetes and chronic kidney disease, depending on eGFR and other factors

doi: 10.1002/ana.26134 104 ChenSZhouMSunJGuoAFernandoRLChenYet al

The physiologic significance of these numerous actions has not been established.25 The pattern of PYY secretion in response to a meal raises the hypothesis that it may play a role as physiologic satiety signal, acting in terminating the meal and stimulating coordinated gastrointestinal responses in order to aid digestion and absorption

There is another mechanism showing that GLP-1RA treatment regulates Ca 2+ levels due to reductions in the ryanodine receptor (RyR)2 phosphorylation and suppression of the activation of calmodulin-dependent protein kinase (CaMK)-II [77]

For GLP-1s, it costs $129 for the first month ($80 off), then $209 per month