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Notably, genes encoding the master regulator of cholesterol, LXR (Nr1h2, Nr1h3), were decreased following semaglutide, whereas the gene encoding FXR (Nr1h4), which increases fatty acid oxidation in liver, was increased

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However, there are situations in which GLP-1 agonists should be discontinued in perioperative care such in cases of acute kidney injury requiring renal replacement therapy and in cases of postoperative ileus (Hurst, et al., 2021)