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& Polonsky, K

As noted, adherence to GLP-1s drops significantly after 6-12 months

When weight loss happens quickly: Estrogen levels can temporarily drop Hormonal signaling between the brain and ovaries can shift Ovulation may be delayed or suppressed This is one reason periods may become irregular during rapid weight loss whether from dieting, stress, illness, or medication

Originally developed as a possible skin cancer prevention aid by increasing pigmentation, Melanotan 2 was later found to also provide tanning effects, along with potential appetite-suppressing and libido-enhancing properties (PubMed, ScienceDirect)