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Eli Lilly and Companys next-generation injectable (retatrutide) is showing even greater weight loss and blood sugar reductions than todays GLP-1s, with ~1517% weight loss in diabetes patients and prior data approaching ~25%+ in obesitypotentially the most effective therapy weve seen to date

NEDA cautions that for people with active eating disorders or a history of disordered eating, these drugs can be harmful when not used for their intended purpose, when inadequately monitored or monitored by clinicians without eating disorder expertise, or when used for weight loss motivated by weight stigma. That doesnt mean GLP-1s are automatically off the table, but it does mean that this decision warrants extra care, specialist input, and close monitoring throughout

doi: 10.1016/j.freeradbiomed.2022.02.021 27

Abstract Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins

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