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Next-generation agents, including triple agonists such as retatrutide, extend beyond GLP-1 and GIP to include glucagon receptor activation, introducing a new dimension of energy expenditure and metabolic regulation

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Have had a blood transfusion or organ transplant within the last three months

The accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFT) formed by tau protein is considered the main pathological feature of this disease (Yang et al., 2017)

Some patients report regaining the weight they lost upon stopping the injections