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Identification and characterization of a novel glutaminase inhibitor

muciniphila secretes a protein called P9 that has been shown to upregulate the expression of glucagon-like peptide-1 (GLP-1), an incretin hormone secreted by the intestinal L-cells ( GLP-1 is known as an insulinotropic hormone, because it induces the release of insulin from pancreatic -cells in response to rising serum glucose levels ( -cells, treatment with GLP-1 induced mitochondrial biogenesis, through a mechanism that involved increased cAMP activation

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2b), confirmed the specific sequence of hsa-let-7c (UGAGGUAGUAGGUUGUAUGGUU), and thus acquired the real-time sequence (Table 1)