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Datos toxicolgicos preclnicos: Los estudios de toxicidad aguda y subaguda en la rata no han evidenciado mortalidad ni toxicidad orgnica significativa, incluso a dosis ampliamente superiores a las dosis teraputicas (hasta 100 veces la dosis eficaz)

Data from DNA dot-blots and mRNA levels of Dnmt and Tet support the activity data (Fig

Studies on the effects of Ang A, a recently discovered novel human Ang-derived peptide, where only the N-terminal amino acid is different from Ang II, have also yielded conflicting results

Phase 1: Establish tirzepatide baseline (weeks 1-4) Start tirzepatide alone at 2.5mg weekly

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