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Extended-Release Stimulants Side Effects of Extended-Release Stimulants Decreased appetite or weight loss Difficulty falling asleep or changes in sleep patterns Headaches Dry mouth Increased heart rate Increased blood pressure Nervousness or anxiety Jaw clenching Teeth grinding Nausea Constipation Feeling jittery, restless, or overstimulated Many people find that they have more noticeable side effects with amphetamines, while methylphenidate may cause fewer physical side effects, says Ditzell