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A lower all-cause dementia risk associated with SGLT2 inhibitors was found among those with atherosclerotic cardiovascular disease (HR [95% CI]: 0.80 [0.680.95]) and renal insufficiency (HR [95% CI]: 0.80 [0.650.99])

Furthermore, cytokines might be involved in communication between the immune system and the CNS and induce neuropsychological manifestations, as hypersecretion of cytokines plays a role in the onset and maintenance of depressive illness [62]

However, lifestyle changes such as increasing protein intake to around 25-30g per meal and incorporating strength and resistance training 2-3 times per week can help combat muscle and bone density loss while taking GLP-1 medications like Ozempic

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