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Survey data are not the same as a randomized controlled trial, but they are consistent with what GLP1 users widely report

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GLP-1 medications work through two primary mechanisms within the brain: Strengthening the blood-brain barrier, which protects against harmful substances 28 Reducing neuroinflammation through specialized brain cells called microglia and astrocytes 29 GLP-1 receptor signaling enhances neuron growth and survival 28