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Fat cells release inflammatory mediators known as adipokines , including: Leptin Adiponectin Interleukin-6 Tumor necrosis factor-alpha These mediators contribute to: Cartilage degradation Synovial inflammation Osteophyte formation Because of these mechanisms, obesity is considered one of the most important modifiable risk factors for knee osteoarthritis

The trial was funded by the Novo Nordisk ISS Scheme who provided funding, the IMP and placebo

Food and waste move through your intestines more slowly

Theres no set calorie target whilst taking Wegovy, but youll likely be eating 1200-2000 calories per day due to the impact of the medication on lowering appetite

What should I do if I miss a dose