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Stage I occurs within the first 24 hours of ingestion and is characterized by the non-specific symptoms of nausea, vomiting, malaise, lethargy and diaphoresis

One study (87) provides evidence that pro-GLP-1 prevented apoptosis induced by oxygen-glucose deprivation (OGD) in cultured cortical neurons, and exerted neuroprotective effects through the cAMP/PKA and PI3K/Akt signaling pathways but not the ERK pathway in mice against cerebral ischemia

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