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doi: 10.1124/dmd.107.015511 [DOI] [PMC free article] [PubMed] [Google Scholar] 214.Pan HC, Chen JY, Chen HY, et al
Steroidogenic Factor-1 (SF-1, encoded by NR5A1), Forkhead box O1 (FOXO1) and Liver receptor homolog-1 (LRH-1, encoded by NR5A2) play essential functional roles within this network ( SF-1 is a key nuclear receptor transcription factor, which controls the development and the functionality of steroidogenic tissues including the adrenal glands, and gonads and is coded by the NR5A1 gene ( Steroid-genic factor-1 (SF-1) transcription factor is upregulated in the process of granulosa-cell differentiation and luteinization, which in turn suggests that SF-1 is essential to the process of specification of granulosa-cell into luteal cells ( SF-1 regulation is performed in two ways: direct transcriptional activity and associations with various co-regulators and signaling cascades
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