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Astrocytes generate an inductive tightening influence on the endothelium through the production of sonic hedgehog (Shh) (Alvarez et al., 2011) and basic fibroblast growth factor (bFGF) (Sobue et al., 1999) that assist in forming a restrictive BBB by promoting endothelial expression of tight junction (TJ) proteins, occludin, claudins, and zonula occludens (ZO)

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Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus

Its copper-binding profile makes it useful in models focused on extracellular matrix behavior, cellular remodeling, and repair-associated signaling

Gut Repair : BPC-157 heals gastrointestinal mucosal damage caused by NSAIDs (ibuprofen and aspirin), alcohol, and inflammatory bowel conditions