Farris SG, McLean CP, Van Meter PE, Simpson HB, Foa EB
Patients with isolated tendon or ligament injuries, post-surgical recovery needs, NSAID-related gut concerns, or chronic musculoskeletal inflammation tend to respond best
Metabolism & Elimination Limited characterization of specific metabolic pathways has been published for both peptides: CJC-1295 (NO DAC): Peptidase-mediated degradation represents primary metabolic pathway Four amino acid substitutions provide enhanced resistance to dipeptidyl peptidase-IV Metabolites and degradation products not fully characterized in published literature Clearance from circulation within hours despite sustained pharmacodynamic effects Ipamorelin: Clearance of 0.078 L/h/kg in human pharmacokinetic studies Rapid elimination from plasma following distribution phase Metabolic pathways likely involve proteolytic cleavage at peptide bonds No significant accumulation observed with repeated dosing in animal models A notable pharmacokinetic-pharmacodynamic disconnect exists: despite relatively short plasma half-lives (30 minutes to 2 hours), growth hormone secretory effects persist for 6+ hours, suggesting either active metabolites, tissue retention, or persistent receptor signaling cascade activation
In the meantime, well continue to fight for patients every single day: helping ensure continuity of care for those already on GLP-1s and enabling new patients to start the most effective treatment available.
The question of who benefits most from pineal peptides comes down to the underlying mechanism driving the sleep problem
