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(38) reported microglia and astrocytes overactivation, increase in proinflammatory cytokines, mitochondrial dysfunction, and abnormal neuronal morphology in the hippocampus of young and old mice subjected to 24 h of sleep deprivation, whereas treatment with urolithin A protected against these adverse effects

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5, May 1991, pp

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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation