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Where IL-6 persists in chronic wounds, causing tissue damage 81 and IL-17 drives neutrophil infiltration and prolonged inflammation 82

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

Results: 1224 admissions from 104 hospitals across the UK were included

The heme degradation pathway, which regulates bilirubin production, conjugation, and excretion, is tightly controlled by enzymatic processes and genetic factors

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