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rectale were found to be associated with differences in the proportion of dietary carbohydrate content

Besides releasing melatonin into the circulation in small amounts (usually levels are in the range of pg/mL), melatonin is also discharged directly into the cerebrospinal fluid (CSF) of the third ventricle and is likely an important primary secretory pathway since the nocturnal elevation in this fluid is roughly an order of magnitude greater than that in the blood ( Figure 1 ) (45)

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