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The SAT1 gene is located on the X chromosome (Xp22.11) and is composed of 7 exons that generate two alternatively spliced mRNAs

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Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination

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[8] Ding L, Xu L, Jin Y, et al

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