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Nissen expects tirzepatide to soon join the pure GLP-1 RAs with an FDA-approved indication for weight loss in addition to diabetes, although it may meet the same payer reluctance around reimbursement for weight loss that the pure GLP-1 RAs have

Our analysis found that patients taking tirzepatide were significantly more likely to achieve weight loss: Those taking tirzepatide were 1.8 times more likely than those taking semaglutide to achieve 5% weight loss, 2.5 times more likely than those taking semaglutide to achieve 10% weight loss, And 3.2 times more likely than those taking semaglutide to achieve 15% weight loss

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doi: 10.3892/mmr.2015.3646 14 LiXLiuXWangYCaoFChenZHuZet al

Putting It All Together MOTS-c sits at the crossroads of mitochondrial function and nuclear gene control