Obesity is a multi-faceted medical condition that typically manifests as a result of several factors, including genetic makeup, use of certain medications, lack of physical activity, excessive calorie consumption and sleep patterns
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Daily injections of AzaA8 (0.4 mg kg 1 , s.c., daily), stabilized body weight relative to vehicle, preventing further gain, while semaglutide (0.04 mg kg 1 , s.c., daily) produced modest weight loss ( Fig
388 Similarly, aluminium and manganese reduce astrocytic glutamate uptake, thus leading to excitotoxicity and secondary neuronal death
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