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Funding This work was supported by Sichuan Province Foundation (2021NZZJ0016), Fok Ying Tung Education Foundation (171019), and the 111 project (D17015)

Different forms of regulated necrosis (necroptosis, pyroptosis and ferroptosis) have been associated with liver disease progression, but the ability of hepatocytes to execute them remains controversial

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Clinical Safety & Considerations Before starting peptide therapy: Get Baseline Labs: IGF-1 Fasting glucose and insulin Lipid panel Thyroid and cortisol markers Monitor: Response to treatment Sleep quality and muscle recovery Adverse effects: water retention, joint pain, injection site irritation Contraindications: Active cancer Uncontrolled diabetes Pregnant or breastfeeding Prior history of pituitary disorders All peptides should be prescribed and monitored by a licensed medical provider using pharmaceutical-grade compounds