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This may be because the latter releases more molecules that signal macrophages to consume them ( via toll-like receptor 2, allowing the clearance of ferroptosis cells ( Macrophages participate in iron regulation by retrieving and scavenging iron from aged erythrocytes, which may lead to macrophage ferroptosis and impair their immunological function ( via increasing activities of the ROS-nuclear factor erythroid 2-related factor 2 (NRF2) signaling, which helps to inhibit ferroptosis in BMDM ( via the Smad pathway

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Kruse, T., Hansen, J