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Such an inflammatory milieu not only exacerbates the structural damage to both the epidermis and dermis, but also establishes a pro-aging microenvironment that underlies the pathogenesis of various age-related cutaneous disorders

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( a ) Ubiquitination of nuclear IDO1 and the binding with KEAP1 in MCF-7 cells treated with 100 M H 2 O 2 was analyzed by Western blot

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While the liver and kidneys handle most detoxification, the skin provides a secondary route, and increased sweating can reduce overall toxin burden

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[PMID: 18990082 DOI: 10.1517/14728220802517901] [DOI] [PubMed] [Google Scholar] 58.Pierson DJ

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