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TIRZEPATIDE Tirzepatide, a single-molecule with a dual-action, given as once weekly injection, targets both the GLP-1 receptor and the glucose-insulin peptide (GIP) receptor (see Fig

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For many people, this combination is safe, but certain side effects may become more noticeable when the medications are taken together

GLP-1 patches and GLP-1 supplements, often marketed as natural or drug-free alternatives, typically do not contain GLP-1 itself

Osmotic laxatives like polyethylene glycol (MiraLAX) may be combined if needed