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Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (step 6): A randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Multivariate analysis showed no difference between placebo and liraglutide arms in HbA1c at 6 months (HbA1c:0.2 mmol/mol, 11.3, 11.6, p = 0.98) however, at 12 months HbA1c was significantly higher in the liraglutide arm (HbA1c:10.9 mmol/mol, 1.1, 20.6, p = 0.032)

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