PREVENT-HF: Primary and secondary prevention of heart failure in high-risk obese patients with GLP-1RA led by Varun Sundaram, M.D., Ph.D., associate professor at Case Western Reserve University School of Medicine
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One placebo-controlled trial, called ATTAIN-MAINTAIN, followed adults who had previously completed the SURMOUNT-5 obesity trial, a randomized controlled study evaluating whether tirzepatide, the active ingredient in Zepbound, led to greater body weight reduction versus semaglutide in adults with obesity
Salvatore T, Galiero R, Caturano A, et al
Therefore, basic and clinical trials further reveal the mechanism of GLP-1 on lipid metabolism, which is helpful to improve our understanding of GLP-1 function and is essential for advancing its clinical application
