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A comprehensive analysis published in PMC found that individuals maintaining 1.2-1.6 grams of protein per kilogram of body weight while using semaglutide preserved significantly more muscle mass during weight loss

Last reviewed: July 2, 2026 Last updated: July 2, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

When patients follow the fasting window, water limits, and timing guidelines carefully, they give the drug the opportunity to work at its full potential

your best choice depends on your health history, goals, and tolerability

The glucagon receptor advantage This is the real story behind the switch