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[DOI] [PubMed] [Google Scholar] 121.Olsen A, Siboska GE, Clark BFC, Rattan SIS
If AED-related weight gain is contributing to your decision to consider Mounjaro, its worth discussing whether an alternative AED might be appropriate before adding another medication
Retatrutide is a synthetic peptide engineered to activate three separate receptor pathways that play important roles in metabolic and endocrine signalling: GLP-1 (Glucagon-Like Peptide-1) Receptors GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptors Glucagon Receptors Unlike many traditional peptide compounds that focus on a single receptor target, Retatrutides triple-agonist activity enables researchers to investigate multiple biological pathways simultaneously
In electrophysiological experiments, exendin-4 increases glutamatergic input onto dopaminergic VTA neurons via activation of presynaptic GLP-1Rs on glutamatergic afferents [99], analogous to the mechanism in the LC described above [91]
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